Severe Falciparum Malaria in Children
Identifieur interne : 002730 ( Main/Exploration ); précédent : 002729; suivant : 002731Severe Falciparum Malaria in Children
Auteurs : Charles R. J. C. Newton [Royaume-Uni] ; Sanjeev Krishna [Royaume-Uni]Source :
- Pharmacology and Therapeutics [ 0163-7258 ] ; 1998.
English descriptors
- Teeft :
- Abdalla, Abnormality, Acidosis, Acidosis study group, Acute falciparum malaria, Acute infection, Acute malaria, Adjunct therapy, Adjunctive, Adult patients, African children, Aikawa, Anaemia, Anaerobic glycolysis, Animal models, Anticonvulsant, Antigenic, Antigenic variation, Antimalarial, Antimalarial drugs, Antimalarial treatment, Antipyretic, Artemether, Artemisinin, Artemisinin derivatives, Asexual, Asian adults, Bacterial meningitis, Berghei, Blackwater, Blackwater fever, Blood cells, Blood group, Blood transfusions, Blood volume, Boonpucknavig, Brainstem, Brewster, Cause death, Cell deformability, Cerebral, Cerebral blood flow, Cerebral blood volume, Cerebral disease, Cerebral involvement, Cerebral malaria, Cerebral oedema, Cerebrospinal, Chloroquine, Clin, Clinical features, Coma, Commey, Convulsion, Copyright, Copyright holder, Cowden, Crawley, Cytoadherence, Cytokine, Deep coma, Derivative, Desferrioxamine, Dichloroacetate, Disease severity, Dos, Dyserythropoiesis, Edington, Electrolyte, Encephalopathy, Endemic, Endemic areas, Endothelial, Endothelial cell activation, Endothelial cells, Energy expenditure, Engl, Erythrocyte, Exchange transfusion, Falciparum, Falciparum infection, Falciparum malaria, Fatal cases, Fatal outcome, Febrile, Febrile convulsions, Further studies, Gambia, Gambian, Gambian children, Gene family, Ghanaian children, Gilles, Glucose, Glycolysis, Gordeuk, Grau, Greenwood, Haematol, Haemoglobin, Haemolysis, Haemorrhage, Hemiparesis, Hensbroek, Herniation, Hien, High mortality, Holloway, Host cells, Host ligands, Host tissues, Hyperlactataemia, Hypoglycaemia, Hypoglycaemic, Hyponatraemia, Immun, Immunol, Immunological, Impairment, Important differences, Infection, Infusion, Intracranial, Intracranial hypertension, Intracranial pressure, Intramuscular, Intravascular, Intravenous, Iron chelation therapy, Kenya, Kenyan, Kenyan children, Kirkham, Knowlesi, Kremsner, Krishna, Kuile, Kwiatkowski, Lactate, Lactate levels, Lactic, Lactic acid, Lactic acidosis, Lancet, Lemercier, Ligand, Loading dose, Looareesuwan, Mabeza, Macaca mulatta, Macrophage, Maegraith, Malaria, Malaria infection, Malaria infections, Malarial, Malawi, Mannitol, Marsh, Mature stages, Mcguire, Mechanical hypothesis, Meningitis, Metabolic, Metabolic acidosis, Metabolism, Migasena, Moderate malaria, Molyneux, Morbidity, Murine, Mwangi, Nash, Neurol, Neurological, Neurological damage, Neurological manifestations, Neurological sequelae, Newton, Nguyen, Nitric, Nitric oxide, Nitrogen oxides, Nonimmune, Nonimmune adults, Normal range, Oedema, Organisation, Other antimalarials, Other causes, Other encephalopathies, Other mechanisms, Paediatric, Painful stimulus, Papua, Paracetamol, Parasitaemia, Parasite, Parasite development, Parasitised, Parasitized, Parasitol, Parenteral, Pasvol, Pathogenesis, Pathol, Pathophysiological, Pathophysiological processes, Pathophysiology, Pediatr, Pentoxifylline, Perfusion, Permeability, Peshu, Peto, Pharmacokinetic, Pharmacokinetics, Phenobarbitone, Phenotype, Placebo, Plasma lactate, Plasmodium, Plasmodium berghei, Plasmodium erythrocytes, Plasmodium falciparum, Plasmodium falciparum malaria, Plasmodium knowlesi, Platelet, Poor outcome, Prbc, Prbcs, Pregnant women, Prognostic, Prognostic significance, Pukrittayakamee, Pyruvate, Quinine, Quinine treatment, Reactive, Reactive nitrogen intermediates, Reactive oxygen species, Recent studies, Regimen, Renal, Renal impairment, Respiratory distress, Ring haemorrhages, Rosette, Rosette formation, Rosetting, Seizure, Sequela, Sequestration, Serum levels, Severe, Severe anaemia, Severe disease, Severe falciparum malaria, Severe infection, Severe malaria, Severe malarial anaemia, Silamut, Skeletal muscle, Sowunmi, Spitz, Stacpoole, Supanaranond, Supportive treatment, Survivor, Syndrome, Systemic effects, Thai, Thai adults, Thrombocytopaenia, Thuma, Toxin, Tran, Trans, Transfusion, Transtentorial herniation, Tropical medicine, Tumor necrosis factor, Tumour, Tumour necrosis factor, Udomsangpetch, Uncomplicated, Uncomplicated falciparum malaria, Uncomplicated infection, Uncomplicated infections, Uncomplicated malaria, Vietnamese adults, Vivax, Waller, Warrell, Waruiru, Watkins, Weatherall, Whilst, Winstanley, World health organisation, Yaman.
Abstract
Abstract: Severe falciparum malaria is one of the most lethal parasitic infections in the world and is responsible for more than one million deaths in African children per year. Changes to management over the last 40 years have not improved survival. A reduction in the mortality and morbidity may only come about by a better understanding of the pathophysiological processes that are responsible for severe disease and that determine the outcome before antimalarials have had time to work. This review discusses potential adjunctive therapies for severe malaria that are under development following such detailed clinical and pathophysiological studies.
Url:
DOI: 10.1016/S0163-7258(98)00008-4
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abdalla</term>
<term>Abnormality</term>
<term>Acidosis</term>
<term>Acidosis study group</term>
<term>Acute falciparum malaria</term>
<term>Acute infection</term>
<term>Acute malaria</term>
<term>Adjunct therapy</term>
<term>Adjunctive</term>
<term>Adult patients</term>
<term>African children</term>
<term>Aikawa</term>
<term>Anaemia</term>
<term>Anaerobic glycolysis</term>
<term>Animal models</term>
<term>Anticonvulsant</term>
<term>Antigenic</term>
<term>Antigenic variation</term>
<term>Antimalarial</term>
<term>Antimalarial drugs</term>
<term>Antimalarial treatment</term>
<term>Antipyretic</term>
<term>Artemether</term>
<term>Artemisinin</term>
<term>Artemisinin derivatives</term>
<term>Asexual</term>
<term>Asian adults</term>
<term>Bacterial meningitis</term>
<term>Berghei</term>
<term>Blackwater</term>
<term>Blackwater fever</term>
<term>Blood cells</term>
<term>Blood group</term>
<term>Blood transfusions</term>
<term>Blood volume</term>
<term>Boonpucknavig</term>
<term>Brainstem</term>
<term>Brewster</term>
<term>Cause death</term>
<term>Cell deformability</term>
<term>Cerebral</term>
<term>Cerebral blood flow</term>
<term>Cerebral blood volume</term>
<term>Cerebral disease</term>
<term>Cerebral involvement</term>
<term>Cerebral malaria</term>
<term>Cerebral oedema</term>
<term>Cerebrospinal</term>
<term>Chloroquine</term>
<term>Clin</term>
<term>Clinical features</term>
<term>Coma</term>
<term>Commey</term>
<term>Convulsion</term>
<term>Copyright</term>
<term>Copyright holder</term>
<term>Cowden</term>
<term>Crawley</term>
<term>Cytoadherence</term>
<term>Cytokine</term>
<term>Deep coma</term>
<term>Derivative</term>
<term>Desferrioxamine</term>
<term>Dichloroacetate</term>
<term>Disease severity</term>
<term>Dos</term>
<term>Dyserythropoiesis</term>
<term>Edington</term>
<term>Electrolyte</term>
<term>Encephalopathy</term>
<term>Endemic</term>
<term>Endemic areas</term>
<term>Endothelial</term>
<term>Endothelial cell activation</term>
<term>Endothelial cells</term>
<term>Energy expenditure</term>
<term>Engl</term>
<term>Erythrocyte</term>
<term>Exchange transfusion</term>
<term>Falciparum</term>
<term>Falciparum infection</term>
<term>Falciparum malaria</term>
<term>Fatal cases</term>
<term>Fatal outcome</term>
<term>Febrile</term>
<term>Febrile convulsions</term>
<term>Further studies</term>
<term>Gambia</term>
<term>Gambian</term>
<term>Gambian children</term>
<term>Gene family</term>
<term>Ghanaian children</term>
<term>Gilles</term>
<term>Glucose</term>
<term>Glycolysis</term>
<term>Gordeuk</term>
<term>Grau</term>
<term>Greenwood</term>
<term>Haematol</term>
<term>Haemoglobin</term>
<term>Haemolysis</term>
<term>Haemorrhage</term>
<term>Hemiparesis</term>
<term>Hensbroek</term>
<term>Herniation</term>
<term>Hien</term>
<term>High mortality</term>
<term>Holloway</term>
<term>Host cells</term>
<term>Host ligands</term>
<term>Host tissues</term>
<term>Hyperlactataemia</term>
<term>Hypoglycaemia</term>
<term>Hypoglycaemic</term>
<term>Hyponatraemia</term>
<term>Immun</term>
<term>Immunol</term>
<term>Immunological</term>
<term>Impairment</term>
<term>Important differences</term>
<term>Infection</term>
<term>Infusion</term>
<term>Intracranial</term>
<term>Intracranial hypertension</term>
<term>Intracranial pressure</term>
<term>Intramuscular</term>
<term>Intravascular</term>
<term>Intravenous</term>
<term>Iron chelation therapy</term>
<term>Kenya</term>
<term>Kenyan</term>
<term>Kenyan children</term>
<term>Kirkham</term>
<term>Knowlesi</term>
<term>Kremsner</term>
<term>Krishna</term>
<term>Kuile</term>
<term>Kwiatkowski</term>
<term>Lactate</term>
<term>Lactate levels</term>
<term>Lactic</term>
<term>Lactic acid</term>
<term>Lactic acidosis</term>
<term>Lancet</term>
<term>Lemercier</term>
<term>Ligand</term>
<term>Loading dose</term>
<term>Looareesuwan</term>
<term>Mabeza</term>
<term>Macaca mulatta</term>
<term>Macrophage</term>
<term>Maegraith</term>
<term>Malaria</term>
<term>Malaria infection</term>
<term>Malaria infections</term>
<term>Malarial</term>
<term>Malawi</term>
<term>Mannitol</term>
<term>Marsh</term>
<term>Mature stages</term>
<term>Mcguire</term>
<term>Mechanical hypothesis</term>
<term>Meningitis</term>
<term>Metabolic</term>
<term>Metabolic acidosis</term>
<term>Metabolism</term>
<term>Migasena</term>
<term>Moderate malaria</term>
<term>Molyneux</term>
<term>Morbidity</term>
<term>Murine</term>
<term>Mwangi</term>
<term>Nash</term>
<term>Neurol</term>
<term>Neurological</term>
<term>Neurological damage</term>
<term>Neurological manifestations</term>
<term>Neurological sequelae</term>
<term>Newton</term>
<term>Nguyen</term>
<term>Nitric</term>
<term>Nitric oxide</term>
<term>Nitrogen oxides</term>
<term>Nonimmune</term>
<term>Nonimmune adults</term>
<term>Normal range</term>
<term>Oedema</term>
<term>Organisation</term>
<term>Other antimalarials</term>
<term>Other causes</term>
<term>Other encephalopathies</term>
<term>Other mechanisms</term>
<term>Paediatric</term>
<term>Painful stimulus</term>
<term>Papua</term>
<term>Paracetamol</term>
<term>Parasitaemia</term>
<term>Parasite</term>
<term>Parasite development</term>
<term>Parasitised</term>
<term>Parasitized</term>
<term>Parasitol</term>
<term>Parenteral</term>
<term>Pasvol</term>
<term>Pathogenesis</term>
<term>Pathol</term>
<term>Pathophysiological</term>
<term>Pathophysiological processes</term>
<term>Pathophysiology</term>
<term>Pediatr</term>
<term>Pentoxifylline</term>
<term>Perfusion</term>
<term>Permeability</term>
<term>Peshu</term>
<term>Peto</term>
<term>Pharmacokinetic</term>
<term>Pharmacokinetics</term>
<term>Phenobarbitone</term>
<term>Phenotype</term>
<term>Placebo</term>
<term>Plasma lactate</term>
<term>Plasmodium</term>
<term>Plasmodium berghei</term>
<term>Plasmodium erythrocytes</term>
<term>Plasmodium falciparum</term>
<term>Plasmodium falciparum malaria</term>
<term>Plasmodium knowlesi</term>
<term>Platelet</term>
<term>Poor outcome</term>
<term>Prbc</term>
<term>Prbcs</term>
<term>Pregnant women</term>
<term>Prognostic</term>
<term>Prognostic significance</term>
<term>Pukrittayakamee</term>
<term>Pyruvate</term>
<term>Quinine</term>
<term>Quinine treatment</term>
<term>Reactive</term>
<term>Reactive nitrogen intermediates</term>
<term>Reactive oxygen species</term>
<term>Recent studies</term>
<term>Regimen</term>
<term>Renal</term>
<term>Renal impairment</term>
<term>Respiratory distress</term>
<term>Ring haemorrhages</term>
<term>Rosette</term>
<term>Rosette formation</term>
<term>Rosetting</term>
<term>Seizure</term>
<term>Sequela</term>
<term>Sequestration</term>
<term>Serum levels</term>
<term>Severe</term>
<term>Severe anaemia</term>
<term>Severe disease</term>
<term>Severe falciparum malaria</term>
<term>Severe infection</term>
<term>Severe malaria</term>
<term>Severe malarial anaemia</term>
<term>Silamut</term>
<term>Skeletal muscle</term>
<term>Sowunmi</term>
<term>Spitz</term>
<term>Stacpoole</term>
<term>Supanaranond</term>
<term>Supportive treatment</term>
<term>Survivor</term>
<term>Syndrome</term>
<term>Systemic effects</term>
<term>Thai</term>
<term>Thai adults</term>
<term>Thrombocytopaenia</term>
<term>Thuma</term>
<term>Toxin</term>
<term>Tran</term>
<term>Trans</term>
<term>Transfusion</term>
<term>Transtentorial herniation</term>
<term>Tropical medicine</term>
<term>Tumor necrosis factor</term>
<term>Tumour</term>
<term>Tumour necrosis factor</term>
<term>Udomsangpetch</term>
<term>Uncomplicated</term>
<term>Uncomplicated falciparum malaria</term>
<term>Uncomplicated infection</term>
<term>Uncomplicated infections</term>
<term>Uncomplicated malaria</term>
<term>Vietnamese adults</term>
<term>Vivax</term>
<term>Waller</term>
<term>Warrell</term>
<term>Waruiru</term>
<term>Watkins</term>
<term>Weatherall</term>
<term>Whilst</term>
<term>Winstanley</term>
<term>World health organisation</term>
<term>Yaman</term>
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<front><div type="abstract" xml:lang="en">Abstract: Severe falciparum malaria is one of the most lethal parasitic infections in the world and is responsible for more than one million deaths in African children per year. Changes to management over the last 40 years have not improved survival. A reduction in the mortality and morbidity may only come about by a better understanding of the pathophysiological processes that are responsible for severe disease and that determine the outcome before antimalarials have had time to work. This review discusses potential adjunctive therapies for severe malaria that are under development following such detailed clinical and pathophysiological studies.</div>
</front>
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<name sortKey="Krishna, Sanjeev" sort="Krishna, Sanjeev" uniqKey="Krishna S" first="Sanjeev" last="Krishna">Sanjeev Krishna</name>
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